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Acute to chronic extrapolations

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hannaholmquist's picture
Acute to chronic extrapolations


In the paper by Rosenbaum et al. (2011) acute to chronic extrapolation factors are suggested (ED50 (kg/lifetime)=LD50 (mg/kg)/26 (non-cancer) and 129 (cancer). These factors were compared to factors derived by Kramer et al. and others so it is clear that the relationship is to be used directly as expressed, i.e. simply dividing an acute LD50 (in the unit mg/kg bw) by the respective factor (26 or 129) to arrive at a ED50 in the unit kg/lifetime) (please correct me if I am wrong).

The extrapolation factors were derived from regression analysis (fig 7 och 8). I am very interested in understanding how the regression was used to arrive at the extrapolation factors. I cannot follow the explanations in the figure texts completely. I have e-mailed the corresponding author of the paper with no reply and decided therefore to try here, as the factors are suggested to be used with USEtox and thus are relevant for the forum.

Thank you in advance.



Rosenbaum, R., M. J. Huijbregts, A. Henderson, M. Margni, T. McKone, D. Meent, M. Hauschild, S. Shaked, D. Li, L. Gold and O. Jolliet (2011). "USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties." The International Journal of Life Cycle Assessment 16(8): 710-727.